Editorials and Perspectives:

Virginia Barbour

How ghost-writing threatens the credibility of medical knowledge and medical journals
Haematologica 2010 95: 1-2. [Full Text] [PDF]  

Peng Ji, Harvey F. Lodish

Rac GTPases play multiple roles in erythropoiesis
Haematologica 2010 95: 2-4. [Full Text] [PDF]  

Mariane de Montalembert, Irene Roberts

Sickle cell disease: primum non nocere (first do no harm)
Haematologica 2010 95: 4-5. [Full Text] [PDF]  

Radek C. Skoda

Hereditary myeloproliferative disorders
Haematologica 2010 95: 6-8. [Full Text] [PDF]  

Adele K. Fielding

Current treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia
Haematologica 2010 95: 8-12. [Full Text] [PDF]  

Carol Moreno, Emili Montserrat

Genetic lesions in chronic lymphocytic leukemia: what’s ready for prime time use?
Haematologica 2010 95: 12-15. [Full Text] [PDF]  

Mirjam H.M. Heemskerk

T-cell receptor gene transfer for the treatment of leukemia and other tumors
Haematologica 2010 95: 15-19. [Full Text] [PDF]  

Original Article:

Human Genome Variation:

Andrew Chase, Thomas Ernst, Andreas Fiebig, Andrew Collins, Francis Grand, Philipp Erben, Andreas Reiter, Stefan Schreiber, Nicholas C.P. Cross

TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals
Haematologica 2010 95: 20-26. Published online October 1, 2009; doi:10.3324/haematol.2009.011536 [Abstract] [Full Text] [PDF] [Chase et al. - Supplementary Appendix]  

Erythropoiesis:

Theodosia A. Kalfa, Suvarnamala Pushkaran, Xiaoling Zhang, James F. Johnson, Dao Pan, Deidre Daria, Hartmut Geiger, Jose A. Cancelas, David A. Williams, Yi Zheng

Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen
Haematologica 2010 95: 27-35. [Abstract] [Full Text] [PDF]  

Eduardo Anguita, Ana Villegas, Francisco Iborra, Aurora Hernández

GFI1B controls its own expression binding to multiple sites
Haematologica 2010 95: 36-46. Published online September 22, 2009; doi:10.3324/haematol.2009.012351 [Abstract] [Full Text] [PDF] [E. Anguita et al - Supplementary Appendix]  

Mesenchymal Stem Cells:

Alexandra Briquet, Sophie Dubois, Sandrine Bekaert, Marie Dolhet, Yves Beguin, André Gothot

Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages
Haematologica 2010 95: 47-56. Published online August 27, 2009; doi:10.3324/haematol.2009.008524 [Abstract] [Full Text] [PDF]  

Bone Marrow Failure:

Joseph B. Moore, IV, Jason E. Farrar, Robert J. Arceci, Johnson M. Liu, Steven R. Ellis

Distinct ribosome maturation defects in yeast models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome
Haematologica 2010 95: 57-64. Published online August 27, 2009; doi:10.3324/haematol.2009.012450 [Abstract] [Full Text] [PDF]  

Hereditary Thrombocytosis:

Luciana Teofili, Fiorina Giona, Lorenza Torti, Tonia Cenci, Bianca Maria Ricerca, Carlo Rumi, Vittorio Nunes, Robin Foà, Giuseppe Leone, Maurizio Martini, Luigi Maria Larocca

Hereditary thrombocytosis caused by MPL^Ser505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis
Haematologica 2010 95: 65-70. Published online August 27, 2009; doi:10.3324/haematol.2009.007542 [Abstract] [Full Text] [PDF] [L. Teofili et al - Supplementary Appendix]  

Acute Myeloid Leukemia:

Xiaoxian Zhao, Shweta Singh, Cecile Pardoux, Jingsong Zhao, Eric D. Hsi, Arie Abo, Wouter Korver

Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia
Haematologica 2010 95: 71-78. Published online July 31, 2009; doi:10.3324/haematol.2009.009811 [Abstract] [Full Text] [PDF]  

Acute Lymphoblastic Leukemia:

Paolo Gorello, Roberta La Starza, Emanuela Varasano, Sabina Chiaretti, Loredana Elia, Valentina Pierini, Gianluca Barba, Lucia Brandimarte, Barbara Crescenzi, Antonella Vitale, Monica Messina, Sara Grammatico, Marco Mancini, Caterina Matteucci, Antonella Bardi, Anna Guarini, Massimo Fabrizio Martelli, Robin Foà, Cristina Mecucci

Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults
Haematologica 2010 95: 79-86. [Abstract] [Full Text] [PDF] [P. Gorello et al. - Supplementary Appendix]  

Josep-Maria Ribera, Albert Oriol, Marcos González, Belén Vidriales, Salut Brunet, Jordi Esteve, Eloy del Potro, Concepción Rivas, Maria-José Moreno, Mar Tormo, Victoria Martín-Reina, Josep Sarrá, Ricardo Parody, Jaime Pérez de Oteyza, Encarna Bureo, Maria-Teresa Bernal on behalf of the Programa Español de Tratamiento en Hematología (PETHEMA) and Grupo Español de Trasplante Hemopoyético (GETH) Groups

Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial
Haematologica 2010 95: 87-95. Published online October 1, 2009; doi:10.3324/haematol.2009.011221 [Abstract] [Full Text] [PDF] [Ribera et al. - Supplementary Appendix][Ribera et al. - Supplementary Appendix]  

Malignant Lymphomas:

Jesse Shustik, Guangming Han, Pedro Farinha, Nathalie A. Johnson, Susana Ben Neriah, Joseph M. Connors, Laurie H. Sehn, Douglas E. Horsman, Randy D. Gascoyne, Christian Steidl

Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP
Haematologica 2010 95: 96-101. Published online October 1, 2009; doi:10.3324/haematol.2009.007203 [Abstract] [Full Text] [PDF]  

Chronic Lymphocytic Leukemia:

Dirk Kienle, Axel Benner, Carolin Läufle, Dirk Winkler, Christof Schneider, Andreas Bühler, Thorsten Zenz, Annett Habermann, Ulrich Jäger, Peter Lichter, Riccardo Dalla-Favera, Hartmut Döhner, Stephan Stilgenbauer

Gene expression factors as predictors of genetic risk and survival in chronic lymphocytic leukemia
Haematologica 2010 95: 102-109. Published online November 30, 2009; doi:10.3324/haematol.2009.010298 [Abstract] [Full Text] [PDF] [Kienle et al. Supplementary Appendix]  

Jianguo Zhuang, Stephen F. Hawkins, Mark A. Glenn, Ke Lin, Gillian G. Johnson, Anthony Carter, John C. Cawley, Andrew R. Pettitt

Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition
Haematologica 2010 95: 110-118. Published online August 27, 2009; doi:10.3324/haematol.2009.010272 [Abstract] [Full Text] [PDF] [Zhuang et al. - Supplementary Appendix]  

Thrombosis:

Petter Quist-Paulsen, Inger Anne Næss, Suzanne C. Cannegieter, Pål R. Romundstad, Sverre C. Christiansen, Frits R. Rosendaal, Jens Hammerstrøm

Arterial cardiovascular risk factors and venous thrombosis: results from a population-based, prospective study (the HUNT 2)
Haematologica 2010 95: 119-125. Published online August 27, 2009; doi:10.3324/haematol.2009.011866 [Abstract] [Full Text] [PDF]  

Cell Therapy and Immunotherapy:

Shao-An Xue, Liquan Gao, Sharyn Thomas, Daniel P. Hart, John Zhao Xue, Roopinder Gillmore, Ralf-Holger Voss, Emma Morris, Hans J. Stauss

Development of a Wilms’ tumor antigen-specific T-cell receptor for clinical trials: engineered patient’s T cells can eliminate autologous leukemia blasts in NOD/SCID mice
Haematologica 2010 95: 126-134. Published online August 13, 2009; doi:10.3324/haematol.2009.006486 [Abstract] [Full Text] [PDF] [Xue et al. Supplementary Appendix]  

Review Article:

Malignant Lymphomas:

Sean H. Lim, Stephen A. Beers, Ruth R. French, Peter W.M. Johnson, Martin J. Glennie, Mark S. Cragg

Anti-CD20 monoclonal antibodies: historical and future perspectives
Haematologica 2010 95: 135-143. Published online September 22, 2009; doi:10.3324/haematol.2008.001628 [Abstract] [Full Text] [PDF]  

Brief Reports:

Hematopoiesis:

Michael R. Tallack, Andrew C. Perkins

Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood
Haematologica 2010 95: 144-147. Published online October 22, 2009; doi:10.3324/haematol.2009.010017 [Abstract] [Full Text] [PDF] [M. Tallack et al. - Supplementary Appendix]  

Chronic Myeloid Leukemia:

Sebastian Kreil, Katherine Waghorn, Thomas Ernst, Andrew Chase, Helen White, Rüdiger Hehlmann, Andreas Reiter, Andreas Hochhaus, Nicholas C.P. Cross on behalf of the German CML Study Group

A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon
Haematologica 2010 95: 148-152. [Abstract] [Full Text] [PDF] [S. Kreil et al - Supplementary Appendix]  

Hodgkin's Lymphoma:

Martin A. Schumacher, Roland Schmitz, Verena Brune, Enrico Tiacci, Claudia Döring, Martin-Leo Hansmann, Reiner Siebert, Ralf Küppers

Mutations in the genes coding for the NF-B regulating factors IB and A20 are uncommon in nodular lymphocyte-predominant Hodgkin’s lymphoma
Haematologica 2010 95: 153-157. Published online July 31, 2009; doi:10.3324/haematol.2009.010157 [Abstract] [Full Text] [PDF]  

Lymphoid Neoplasms:

David Krieger, Anja Moericke, Ilske Oschlies, Martin Zimmermann, Martin Schrappe, Alfred Reiter, Birgit Burkhardt

Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia
Haematologica 2010 95: 158-162. Published online July 7, 2009; doi:10.3324/haematol.2009.007526 [Abstract] [Full Text] [PDF] [Krieger et al. Appendix]  

Multiple Myeloma:

Jo Caers, Dirk Hose, Ine Kuipers, Tomas Jan Bos, Els Van Valckenborgh, Eline Menu, Elke De Bruyne, Hartmut Goldschmidt, Ben Van Camp, Bernard Klein, Karin Vanderkerken

Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma
Haematologica 2010 95: 163-167. Published online October 14, 2009; doi:10.3324/haematol.2009.006411 [Abstract] [Full Text] [PDF] [Caers et al. Supplemental Appendix]  

Letters to the Editor:

Congenital Neutropenia:

Marina Lanciotti, Stefania Indaco, Sonia Bonanomi, Tiziana Coliva, Elena Mastrodicasa, Gianluca Caridi, Michaela Calvillo, Carlo Dufour

Novel HAX1 gene mutations associated to neurodevelopment abnormalities in two Italian patients with severe congenital neutropenia
Haematologica 2010 95: 168-169. [Full Text] [PDF]  

Acute Promyelocytic Leukemia:

Sumimasa Nagai, Yasuhito Nannya, Shunya Arai, Yumiko Yoshiki, Tsuyoshi Takahashi, Mineo Kurokawa

Molecular or cytogenetic monitoring and preemptive therapy for central nervous system relapse of acute promyelocytic leukemia
Haematologica 2010 95: 169-171. [Full Text] [PDF]  

Friedrich Stölzel, Martin Wermke, Christoph Röllig, Christian Thiede, Uwe Platzbecker, Martin Bornhäuser

Mobilization of PML/RAR negative peripheral blood stem cells with a combination of G-CSF and CXCR4 blockade in relapsed acute promyelocytic leukemia pre-treated with arsenic trioxide
Haematologica 2010 95: 171-172. Published online October 8, 2009; doi:10.3324/haematol.2009.016568 [Full Text] [PDF]  

Disorders of Hemostasis:

Manuela Platè, Stefano Duga, Luciano Baronciani, Silvia La Marca, Valentina Rubini, Pier Mannuccio Mannucci, Augusto B. Federici, Rosanna Asselta

Premature termination codon mutations in the von Willebrand factor gene are associated with allele-specific and position-dependent mRNA decay
Haematologica 2010 95: 172-174. Published online September 22, 2009; doi:10.3324/haematol.2009.012336 [Full Text] [PDF] [M. Plate et al - Supplementary Appendix]  

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