Haematologica
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Published online 26 March 2008
Haematologica, Vol 93, Issue 5, 780-783 doi:10.3324/haematol.12424
Copyright © 2008 by Ferrata Storti Foundation
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Malignant Lymphomas

Clinical and demographic characteristics of Epstein-Barr virus-associated childhood Burkitt’s lymphoma in Southeastern Brazil: epidemiological insights from an intermediate risk region

Rocio Hassan1, Claudete Esteves Klumb2, Fabricio E. Felisbino1, Deisy M. Guiretti1, Lídia R. White1, Claudio Gustavo Stefanoff1, Mario Henrique M. Barros1, Héctor N. Seuánez3,4, Ilana R. Zalcberg1

1 Bone Marrow Transplantation Centre (CEMO)
2 Hematology Service
3 Genetics Division, Instituto Nacional de Câncer (INCA)
4 Genetics Department, Universidade Federal do Rio de Janeiro (HNS), Rio de Janeiro, RJ, Brazil

Correspondence: Rocio Hassan, PhD, Instituto Nacional de Câncer, INCA-Bone Marrow Transplantation Centre (CEMO). Praça da Cruz Vermelha 23, 6th floor, 20230-130, Rio de Janeiro, RJ, Brazil. E-mail: biomol{at}inca.gov.br

We studied a group of 54 children with Burkitt’s lymphoma from Southeastern Brazil, where epidemiological status of Burkitt’s lymphoma is poorly understood. Epstein-Barr virus association showed an intermediate frequency (~60%) between endemic and sporadic subtypes. Median age was five years. Epstein-Barr virus infection was significantly associated to low age (Epstein-Barr virus+ four years vs. Epstein-Barr virus– eight years). Sex ratio (M:F) was 2:1, with a significantly higher number of males in old age classes. Young age at diagnosis and excess of males at older ages, as well as a causal relationship between low age, epstein-barr virus and Burkitt’s lymphoma risk, may characterize Burkitt’s lymphoma in Brazil.

Key words: Burkitt’s lymphoma, Epstein-Barr virus, clinico-demographic, Brazil.






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Copyright © 2008 by the Ferrata Storti Foundation.