Haematologica
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Published online 26 March 2008
Haematologica, Vol 93, Issue 5, 770-774 doi:10.3324/haematol.12265
Copyright © 2008 by Ferrata Storti Foundation
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Chronic Myeloid Leukemia

Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-{alpha}: 5-year outcome

Francesca Palandri1, Ilaria Iacobucci1, Fausto Castagnetti1, Nicoletta Testoni1, Angela Poerio1, Marilina Amabile1, Massimo Breccia2, Tamara Intermesoli3, Francesco Iuliano4, Giovanna Rege-Cambrin5, Mario Tiribelli6, Maurizio Miglino7, Fabrizio Pane8, Giuseppe Saglio5, Giovanni Martinelli1, Gianantonio Rosti1, Michele Baccarani2, on behalf of the GIMEMA Working Party on CML

1 Department of Hematology/Oncology "L. and A. Seràgnoli" S. Orsola Malpighi Hospital, University of Bologna, Bologna
2 Department of Cellular Biotechnology and Hematology, University "La Sapienza", Rome
3 Hematology Section, Bergamo
4 Division of Hematology, Catanzaro
5 Department of Clinical and Biological Science, University of Turin at Orbassano, Turin
6 Division of Hematology, University of Udine, Udine
7 Division of Hematology, University of Genova, Genova and
8 CEINGE Biotecnologie Avanzate and Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Naples, Italy

Correspondence: Francesca Palandri, Department of Hematology and Oncology "L. and A. Seràgnoli", St. Orsola-Malpighi University Hospital, via Massarenti 9, 40138 Bologna, Italy. E-mail: francesca.palandri{at}libero.it

In 2004, we reported the short-term results of a multicentric, phase 2 study of imatinib 400 mg daily and pegylated interferon-{alpha} in the treatment of 76 early chronic phase Philadelphia-positive chronic myeloid leukemia patients. In this report, we update the results with an observation time of five years. After two years of treatment, all but 10 patients (13%) had discontinued pegylated interferon-{alpha}. The complete cytogenetic response rate at five years was 87%, and 94% of complete cytogenetic responders maintained the complete cytogenetic response after five years. All but one complete cytogenetic response also achieved a major molecular response. These data confirm the excellent response to imatinib front-line and the stability of the complete cytogenetic response. Any possible additional benefit of the combination with interferon-{alpha} remains uncertain, due to low patient compliance.

Key words: chronic myeloid leukemia, imatinib, long-term results, interferon-alpha.






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