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Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization

¹ Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden and
² Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Correspondence: Melissa van Pel, PhD, Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, E3-Q, P.O. box 9600, 2300 RC Leiden, The Netherlands. E-mail:m.van_pel{at}lumc.nl

CD97 is broadly expressed on hematopoietic cells and is involved in neutrophil migration. Since neutrophils are key regulators in HSC/HPC mobilization, we studied a possible role for CD97 in interleukin-8 and granulocyte-colony stimulating factor-induced HSC/HPC mobilization. Mobilization was absent in mice receiving CD97 mAb followed by interleukin-8, while granulocyte-colony stimulating factor-induced mobilization remained unaltered following anti-CD97 administration. Furthermore, combined administration of CD97 mAb and IL-8 induced a significant reduction in the neutrophilic compartment. We hypothesize that the absence of interleukin-8-induced HSC/HPC mobilization after CD97 mAb administration is due to its effect on neutrophil function.

Key words: stem cell mobilization, CD97, interleukin-8, granulocyte-colony stimulating factor, animal models.

This article has been cited by other articles:

				M. van Pel, H. Hagoort, J. Hamann, and W. E. Fibbe CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells Haematologica, August 1, 2008; 93(8): 1137 - 1144. [Abstract] [Full Text] [PDF]