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Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins

Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece

Correspondence: Kostas Stamatopoulos, M.D., Hematology Department and HCT Unit, G. Papanicolaou Hospital, 57010 Thessaloniki, Greece. Phone: international +30.2310350538., Fax: international +30.2310350579. E-mail: kostas.stamatopoulos{at}gmail.com

We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.

Key words: chronic lymphocytic leukemia, cytogenetic diagnosis, FISH, immunoglobulin genes, hematopoietic recovery.